FELINE INFECTIOUS PERITONITIS (FIP)

Most cats infected with feline enteric coronavirus (FeCV) show no signs of disease or mild self limiting gastrointestinal or respiratory signs. In the small number of patients where FIP occurs a mutation of the virus infects white blood cells spreading throughout the body (feline infectious peritoneal virus). As the body’s immune system reacts to the virus a severe inflammatory reaction occurs leading to FIP.

Cause:

  • FeCV mutation leading to

History/Clinical signs:

 

CLINICAL APPROACH/DIAGNOSIS:

The diagnosis of cat flu or at least a strong suspicion of it can be gained from the history and clinical signs.

Diagnosis if necessary, via oropharyngeal swab and PCR

 

TREATMENT

In cases where there is a strong suspicion of cat flu, it can be appropriate to trial treatment:

·       Symptomatic/supportive treatments:

-        NSAIDs to reduce inflammation, bring down any pyrexia

-        Mucolytics (bromhexine)

-        Wiping nasal discharges

-        Use of steam (nebulisation or keep shower or in bathroom at home)

-        Tempt to eat, warm food (lack of smell may affect appetite, warming helps)

-        Appetite stimulants may be helpful in anorexic cases

-        Severe cases with dehydration will need IVFT

·       Antibiotics:

-        Not required in certain cases that are systemically well

-        Indicated for secondary bacterial infections in unwell cats e.g. purulent nasal discharge, pyrexia, off food

-        Example choices include doxycycline, potentiated amoxicillin, cefovecin etc.

·       Topical ophthalmic antibiotic preparations:

-        For secondary conjunctivitis

·       Other:

-        Antivirals e.g.  Oral Famciclovir

  • May be beneficial in managing severe FHV infection

  • Topical antiviral preparations for FHV associated ocular disease are also available e.g. Trifluorothymidine ointment

  • Interferons may help in acute cat flu cases

-        L-lysine supplementation may be of some help with FHV

Prevention/control:

·       Vaccination

-        For FHV and FCV

-        Greatly reduces the risk of URT infections

-        Important for both indoor and outdoor cats

-        Cannot always 100% stop infection but cats tend to get a milder form if vaccinated

-        Some cats may have been exposed before the opportunity to vaccinate

·       Isolation and hygiene

-        The viruses are very infectious and can be shed into/infect the environment

-        Isolation of cats with clinical signs and good hygiene is essential in multi-cat households and rescue centres to try to control the disease

 

If no improvement:

·       Add in antibiotics if not already on them

·       Admit for supportive therapy

·       Screen for FeLV/FIV

·       Consider investigations to rule out other causes of sneezing and nasal discharge

 

The budget option:

If cats can be managed at home this reduces treatment costs.

 

CHRONIC RHINITIS

Cats suffer from chronic rhinitis often as a sequelae to many URT infections – particularly from FHV.

Cats present with chronic ‘snuffles’ or recurring conjunctivitis/sneezing and nasal discharge.

It can be very difficult to treat; many cases require intermittent antibiotic use.

An extended 6-week doxycycline course can be beneficial in these cases along with supportive treatments (Famciclovir L-lysine etc.). Prednisolone in some cases

It is important to rule out FeLV/FIV

In cases with a suspect stress component - helping this may help to decrease the frequency of the URT infection episodes (Feliway, L-tryptophan etc.)